While short-term usage may just produce little, transient effects in the brain, prolonged substance usage alters the brain in fundamental methods that enhance continued usage, such as the conditioning of memory circuits associated with drug taking. Hints that are social (such as being around substance-using pals), geographical (former preferred bars), and physical (experiencing tension) in nature end up being strongly related to the drug.Brain changes from persistent drug or alcohol use can persist years after a person quits. This is why individuals run the risk of relapse even after extended periods of abstinence, and despite a regression's possibly disastrous impacts. More notably, this is why treatment depends on the type of drug and the individual characteristics of the patient.