While short-term use might only produce little, transient effects in the brain, extended substance usage alters the brain in essential manner ins which strengthen continued use, such as the strengthening of memory circuits related to drug taking. Cues that are social (such as being around substance-using buddies), geographical (previous preferred bars), and physical (experiencing stress) in nature end up being highly associated with the drug.Brain changes from persistent drug or alcohol use can continue years after a person stops. This is why individuals risk regression even after long durations of abstaining, and despite a regression's possibly disastrous effects. More significantly, this is why treatment depends on the type of drug and the private attributes of the client.