While short-term usage may only produce little, short-term results in the brain, extended substance use alters the brain in basic manner ins which reinforce continued usage, such as the fortifying of memory circuits associated with drug taking. Cues that are social (such as being around substance-using friends), geographic (previous preferred bars), and physical (experiencing tension) in nature end up being strongly connected with the drug.Brain modifications from persistent drug or alcohol usage can persist years after an individual gives up. This is why individuals risk regression even after long periods of abstinence, and despite a relapse's potentially destructive impacts. More importantly, this is why treatment depends on the kind of drug and the private qualities of the client.