However, few research studies have actually concentrated on aortic valve illness, partly since it had actually long been taken into consideration a passive, "degenerative", "damage" illness. The largest tests, including researches in patients with mild kinds of disease, have focused mainly on the duty of statins in stopping the progression of aortic valve disease as well as have actually created disappointing outcomes. Although not certain, it is likely that the absence of genuine observed advantage relates to the timing of therapy.